Affiliation:
1. Cancer Cell Biology, Harvard School of Public Health,1 and
2. Department of Genetics, Harvard Medical School,2 Boston, Massachusetts 02115
Abstract
ABSTRACT
Exposure to carcinogenic alkylating agents, oxidizing agents, and ionizing radiation modulates transcript levels for over one third of
Saccharomyces cerevisiae's
6,200 genes. Computational analysis delineates groups of coregulated genes whose upstream regions bear known and novel regulatory sequence motifs. One group of coregulated genes contain a number of DNA excision repair genes (including the
MAG1
3-methyladenine DNA glycosylase gene) and a large selection of protein degradation genes. Moreover, transcription of these genes is modulated by the proteasome-associated protein Rpn4, most likely via its binding to
MAG1
upstream repressor sequence 2-like elements, that turn out to be almost identical to the recently identified proteasome-associated control element (G. Mannhaupt, R. Schnall, V. Karpov, I. Vetter, and H. Feldmann, FEBS Lett. 450:27–34, 1999). We have identified a large number of genes whose transcription is influenced by Rpn4p.
Publisher
American Society for Microbiology
Subject
Cell Biology,Molecular Biology
Cited by
304 articles.
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