Contribution of FliC to Epithelial Cell Invasion by Enterohemorrhagic Escherichia coli O113:H21-Reference-Cited by-同舟云学术

Contribution of FliC to Epithelial Cell Invasion by Enterohemorrhagic Escherichia coli O113:H21

Published:2006-12 Issue:12 Volume:74 Page:6999-7004
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Luck Shelley N.¹,Badea Luminita¹,Bennett-Wood Vicki²,Robins-Browne Roy²,Hartland Elizabeth L.¹

Affiliation:

1. Australian Bacterial Pathogenesis Program, Department of Microbiology, Monash University, Melbourne, Victoria 3800

2. Australian Bacterial Pathogenesis Program, Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria 3010, Australia

Abstract

ABSTRACT Enterohemorrhagic Escherichia coli (EHEC) O113:H21 can invade epithelial cells. In this study, we found that invasion but not adherence was inhibited by anti-FliC H21 specific antibodies. In addition, deletion of fliC H21 from EHEC O113:H21 resulted in an eightfold decrease in invasion that was restored upon transcomplementation with fliC H21 but not with fliC H6 . These results suggested that FliC plays an important role in the pathogenesis of infections caused by EHEC O113:H21 by allowing bacteria to penetrate the intestinal epithelium.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00435-06

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