Cryptococcus neoformans Evades Pulmonary Immunity by Modulating Xylose Precursor Transport-Reference-Cited by-同舟云学术

Cryptococcus neoformans Evades Pulmonary Immunity by Modulating Xylose Precursor Transport

Published:2020-07-21 Issue:8 Volume:88 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Li Lucy X.¹,Hole Camaron R.¹,Rangel-Moreno Javier²,Khader Shabaana A.¹,Doering Tamara L.¹^ORCID

Affiliation:

1. Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA

2. Department of Medicine, Allergy/Immunology, and Rheumatology, University of Rochester School of Medicine, Rochester, New York, USA

Abstract

Cryptococcus neoformans is a fungal pathogen that kills almost 200,000 people each year and is distinguished by abundant and unique surface glycan structures that are rich in xylose. A mutant strain of C. neoformans that cannot transport xylose precursors into the secretory compartment is severely attenuated in virulence in mice yet surprisingly is not cleared. We found that this strain failed to induce the nonprotective T helper cell type 2 (Th2) responses characteristic of wild-type infection, instead promoting sustained interleukin 12p40 (IL-12p40) induction and increased IL-17A (IL-17) production.

Funder

HHS | National Institutes of Health

HHS | NIH | National Institute of Allergy and Infectious Diseases

Washington University in St. Louis

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00288-20

Reference39 articles.

1. Cryptococcus neoformans and Cryptococcus gattii, the Etiologic Agents of Cryptococcosis

2. Minimizing fungal disease deaths will allow the UNAIDS target of reducing annual AIDS deaths below 500 000 by 2020 to be realized

3. Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis

4. Wozniak KL, Levitz SM. 2011. T cell and dendritic cell immune responses to Cryptococcus, p 387–396. In Heitman J, Kozel TR, Kwon-Chung KJ, Perfect JR, Casadeval A (ed), Cryptococcus. ASM Press, Washington, DC.

5. Robust Th1 and Th17 Immunity Supports Pulmonary Clearance but Cannot Prevent Systemic Dissemination of Highly Virulent Cryptococcus neoformans H99

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Dendritic Cells: Multifunctional Roles in Host Defenses to Cryptococcus Infections;Journal of Fungi;2023-10-26

2. Two nucleotide sugar transporters are important for cell wall integrity and full virulence of Magnaporthe oryzae;Molecular Plant Pathology;2023-02-12

3. Human Airway Epithelium Responses to Invasive Fungal Infections: A Critical Partner in Innate Immunity;Journal of Fungi;2022-12-27

4. Genomic Variation across a Clinical Cryptococcus Population Linked to Disease Outcome;mBio;2022-12-20

5. RNAi machinery regulates nutrient metabolism and fluconazole resistance in the pathogenic fungusCryptococcus deneoformans;Medical Mycology;2022-12-10