Affiliation:
1. Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio
Abstract
ABSTRACT
Helicobacter
infections are present in approximately 50% of humans, causing severe illnesses such as gastritis and malignancies. Dendritic cells (DC) are critical antigen-presenting cells which link innate and adaptive immune responses. The mechanism of dendritic cell regulation in
Helicobacter
-induced gastritis is poorly understood. These studies characterized DC isolated from the lamina propria of
Helicobacter
-infected mice and analyzed innate and adaptive immune responses elicited by
Helicobacter
antigen (Ag)-pulsed DC. The presence of DC was elevated in the gastric lamina propria infiltrate of infected mice in comparison with controls. After treatment with
Helicobacter felis
Ag, DC were polarized to secrete interleukin-6 as the dominant cytokine. In the presence of DC and
Helicobacter
Ag, responder allogeneic T cells in culture exhibited limited cell division. We suggest that the response of DC and T cells to
Helicobacter
Ag is critical to the chronic persistence of
Helicobacter
-induced gastritis.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
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