Affiliation:
1. Institute of Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig, Leipzig, Germany
2. Head Department of Microbiology, Faculty of Pharmacy, University of Lille, Lille, France
Abstract
ABSTRACT
The antimicrobial activities of garenoxacin and eight other antibiotics against 641 anaerobic isolates were evaluated with the NCCLS agar dilution method. Overall, the MICs of garenoxacin for 50 and 90% of the strains tested (in micrograms per milliliter) were as follows:
Bacteroides fragilis
group, 0.5 and 2;
Prevotella
spp., 0.25 and 2;
Fusobacterium
spp., 0.25 and 0.5;
Porphyromonas
spp., 0.125 and 0.25;
Bilophila wadsworthia
, 0.5 and 1;
Veillonella
spp., 0.25 and 0.5;
Clostridium
spp., 0.25 and 1;
Clostridium difficile
, 2 and >64;
Bifidobacterium
spp., 1 and 2;
Eggerthella lenta
, 0.25 and 1;
Propionibacterium
spp., 0.5 and 0.5; gram-positive cocci, 0.125 and 0.25.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference31 articles.
1. Acar, J., G. Carret, J. D. Cavallo, H. Chardon, P. Choutet, P. Courvalin, H. Dabernat, H. Drugeon, L. Dubreuil, F. Goldstein, V. Jarlier, R. Leclercq, M. H. Nicolas-Chanoine, A. Philippon, B. Rouveix, J. Sirot, C. J. Soussy, and A. Thabaut. 1998. Communiqué de l'antibiogramme de la Société Française de Microbiologie. Valeurs critiques pour l'antibiogramme. Pathol. Biol.46:1-16.
2. Ackermann, G., R. Schaumann, B. Pless, M. C. Claros, E. J. C. Goldstein, and A. C. Rodloff. 2000. Comparative activity of moxifloxacin in vitro against obligately anaerobic bacteria. Eur. J. Microbiol. Infect. Dis.19:228-232.
3. Resistance to Moxifloxacin in Toxigenic
Clostridium difficile
Isolates Is Associated with Mutations in
gyrA
4. Ackermann, G., Y. Tang, A. C. Rodloff, J. Silva, Jr., S. H. Cohen, and P. Heisig. 2001. In vitro activity of sitafloxacin against Clostridium difficile. J. Antimicrob. Chemother.47:722-723.
5. Multicenter Survey of the Changing In Vitro Antimicrobial Susceptibilities of Clinical Isolates of
Bacteroides fragilis
Group,
Prevotella, Fusobacterium, Porphyromonas
, and
Peptostreptococcus
Species
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