Genome Sequencing of Wastewater Confirms the Arrival of the SARS-CoV-2 Omicron Variant at Frankfurt Airport but Limited Spread in the City of Frankfurt, Germany, in November 2021

Author:

Agrawal Shelesh1ORCID,Orschler Laura1,Tavazzi Simona2,Greither Robert3,Gawlik Bernd Manfred2,Lackner Susanne1

Affiliation:

1. Technical University of Darmstadt, Department of Civil and Environmental Engineering Sciences, Institute IWAR, Chair of Water and Environmental Biotechnology, Darmstadt, Germany

2. European Commission, Joint Research Centre, Ispra, Varese, Italy

3. Life Technologies, Darmstadt, Germany

Abstract

Wastewater-based severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) surveillance of Frankfurt Airport by genome sequencing was used to detect SARS-CoV-2 variants entering the region. In November 2021, we found all characteristic mutations of Omicron in wastewater originating from Frankfurt Airport before the first confirmed clinical report from an arriving passenger on 26 November 2021.

Funder

European Commission

Publisher

American Society for Microbiology

Subject

Genetics,Immunology and Microbiology (miscellaneous),Molecular Biology

Reference6 articles.

1. World Health Organization. 26 November 2021. Classification of Omicron (B.1.1.529): SARS-CoV-2 variant of concern. https://www.who.int/news/item/26-11-2021-classification-of-omicron-(b.1.1.529)-sars-cov-2-variant-of-concern.

2. A dynamic nomenclature proposal for SARS-CoV-2 lineages to assist genomic epidemiology

3. European Centre for Disease Prevention and Control. 2021. Risk related to the spread of new SARS-CoV-2 variants of concern in the EU/EEA: first update. European Centre for Disease Prevention and Control, Solna, Sweden.

4. European Centre for Disease Prevention and Control. 2021. Implications of the emergence and spread of the SARS-CoV-2 B.1.1.529 variant of concern (Omicron) for the EU/EEA. European Centre for Disease Prevention and Control, Solna, Sweden.

5. A pan-European study of SARS-CoV-2 variants in wastewater under the EU Sewage Sentinel System

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