Activity of Omadacycline in Rat Methicillin-Resistant Staphylococcus aureus Osteomyelitis-Reference-Cited by-同舟云学术

Activity of Omadacycline in Rat Methicillin-Resistant Staphylococcus aureus Osteomyelitis

Published:2022-01-18 Issue:1 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Karau Melissa J.¹,Schmidt-Malan Suzannah M.¹,Cunningham Scott A.¹,Mandrekar Jayawant N.²,Pritt Bobbi S.¹^ORCID,Keepers Tiffany R.³,Serio Alisa W.³,Chitra Surya³,Patel Robin¹⁴^ORCID

Affiliation:

1. Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA

2. Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA

3. Paratek Pharmaceuticals, Inc., King of Prussia, Pennsylvania, USA

4. Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA

Abstract

Omadacycline, vancomycin, and rifampin, as well as rifampin combination therapies, were evaluated in an experimental rat model of methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis. All treatment groups had less MRSA recovered than saline-treated animals.

Funder

Paratek Pharmaceuticals

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01703-21

Reference43 articles.

1. Clinical Practice Guidelines by the Infectious Diseases Society of America for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections in Adults and Children

2. A comprehensive review of bacterial osteomyelitis with emphasis on Staphylococcus aureus

3. Staphylococcus aureus Osteomyelitis: Bone, Bugs, and Surgery

4. Prevention and treatment ofStaphylococcus aureusbiofilms

5. Biofilms in periprosthetic orthopedic infections

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