Staphylococcus aureus Osteomyelitis: Bone, Bugs, and Surgery

Author:

Urish Kenneth L.1234,Cassat James E.56789

Affiliation:

1. Arthritis and Arthroplasty Design Group, The Bone and Joint Center, Magee-Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

2. Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

3. Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA

4. Department of Bioengineering, and Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

5. Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

6. Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, USA

7. Department of Pediatrics, Division of Pediatric Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, USA

8. Vanderbilt Institute for Infection, Immunology, and Inflammation (VI4), Vanderbilt University Medical Center, Nashville, Tennessee, USA

9. Vanderbilt Center for Bone Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

Abstract

Osteomyelitis, or inflammation of bone, is most commonly caused by invasion of bacterial pathogens into the skeleton. Bacterial osteomyelitis is notoriously difficult to treat, in part because of the widespread antimicrobial resistance in the preeminent etiologic agent, the Gram-positive bacterium Staphylococcus aureus . Bacterial osteomyelitis triggers pathological bone remodeling, which in turn leads to sequestration of infectious foci from innate immune effectors and systemically delivered antimicrobials.

Funder

Musculoskeletal Tissue Foundation

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Center for Advancing Translational Sciences

Burroughs Wellcome Fund

HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases

Orthopaedic Research and Education Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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