Affiliation:
1. Division of Molecular and Radiation Biophysics, Petersburg Nuclear Physics Institute, Russian Academy of Sciences, Gatchina/St. Petersburg, Russia
Abstract
ABSTRACT
The
Desulfurococcus amylolyticus
RadA protein (RadA
Da
) promotes recombination at temperatures approaching the DNA melting point. Here, analyzing ATPase of the RadA
Da
presynaptic complex, we described other distinguishing characteristics of RadA
Da
. These include sensitivity to NaCl, preference for lengthy single-stranded DNA as a cofactor, protein activity at temperatures of over 100°C, and bimodal ATPase activity. These characteristics suggest that RadA
Da
is a founding member of a new class of archaeal recombinases.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
8 articles.
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