Evaluation of the Modified Two-Tiered Testing Method for Diagnosis of Lyme Disease in Children-Reference-Cited by-同舟云学术

Evaluation of the Modified Two-Tiered Testing Method for Diagnosis of Lyme Disease in Children

Published:2019-10 Issue:10 Volume:57 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Lipsett Susan C.¹^ORCID,Branda John A.²,Nigrovic Lise E.¹

Affiliation:

1. Division of Emergency Medicine, Boston Children’s Hospital, Boston, Massachusetts, USA

2. Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA

Abstract

Conventional two-tiered testing (CTTT) for Lyme disease includes a first-tier enzyme immunoassay (EIA) followed by a supplemental immunoblot, and modified two-tiered testing (MTTT) relies on two different sequential EIAs without the inclusion of an immunoblot. MTTT has shown promising results as an alternative strategy for the diagnosis of Lyme disease in adults but has not yet been evaluated in children.

Funder

Boston Children's Hospital Medical Staff Organization

Boston Children's Hospital Michael Shannon Award

Global Lyme Alliance

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00547-19

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