Nuclear Phosphatidylinositol 5-Phosphatase Is Essential for Allelic Exclusion of Variant Surface Glycoprotein Genes in Trypanosomes-Reference-Cited by-同舟云学术

Nuclear Phosphatidylinositol 5-Phosphatase Is Essential for Allelic Exclusion of Variant Surface Glycoprotein Genes in Trypanosomes

Published:2019-02 Issue:3 Volume:39 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Cestari Igor¹,McLeland-Wieser Hilary¹,Stuart Kenneth¹²

Affiliation:

1. Center for Infectious Disease Research, Seattle, Washington, USA

2. Department of Global Health, University of Washington, Seattle, Washington, USA

Abstract

Allelic exclusion of variant surface glycoprotein (VSG) genes is essential for African trypanosomes to evade the host antibody response by antigenic variation. The mechanisms by which this parasite expresses only one of its ∼2,000 VSG genes at a time are unknown.

Funder

National Institutes of Health

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00395-18

Reference58 articles.

1. Transcriptional Regulation of Telomeric Expression Sites and Antigenic Variation in Trypanosomes

2. Isolation of the repertoire of VSG expression site containing telomeres of Trypanosoma brucei 427 using transformation-associated recombination in yeast