Complement Potentiates Immune Sensing of HIV-1 and Early Type I Interferon Responses-Reference-Cited by-同舟云学术

Complement Potentiates Immune Sensing of HIV-1 and Early Type I Interferon Responses

Published:2021-10-26 Issue:5 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Posch Wilfried¹,Bermejo-Jambrina Marta¹²,Steger Marion¹³,Witting Christina¹,Diem Gabriel¹,Hörtnagl Paul⁴,Hackl Hubert⁵,Lass-Flörl Cornelia¹,Huber Lukas A.⁶,Geijtenbeek Teunis B. H.²,Wilflingseder Doris¹^ORCID

Affiliation:

1. Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria

2. Department of Experimental Immunology, Amsterdam Infection and Immunity Institute, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands

3. Institute of Human Genetics, Medical University of Innsbruck, Innsbruck, Austria

4. Central Institute for Blood Transfusion and Immunological Department, Innsbruck, Austria

5. Institute of Bioinformatics, Biocenter Innsbruck, Medical University of Innsbruck, Innsbruck, Austria

6. Institute of Cell Biology, Biocenter Innsbruck, Medical University of Innsbruck, Innsbruck, Austria

Abstract

Importantly, our study highlights an unusual target on DCs—the α chain of complement receptor 4 (CR4) (CD11c)—for therapeutic interventions in HIV-1 treatment. Targeting CD11c on DCs mediated a potent antiviral immune response via clustering of CR4 and CCR5 and subsequent opening of an antiviral recognition pathway in DCs via MAVS.

Funder

Austrian Science Fund

Austrian National Bank

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02408-21

Reference57 articles.

1. Intracellular sensing of complement C3 activates cell autonomous immunity

2. Complement-Opsonized HIV-1 Overcomes Restriction in Dendritic Cells