Intracellular sensing of complement C3 activates cell autonomous immunity

Author:

Tam Jerry C. H.1,Bidgood Susanna R.1,McEwan William A.1,James Leo C.1

Affiliation:

1. Medical Research Council Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.

Abstract

Bringing in the agent of your own destruction Cells need mechanisms to detect and disable pathogens that infect them. Tam et al. now show that complement C3, a protein that binds to pathogens in the blood, can enter target cells together with the pathogen. Once inside the cell, the presence of C3 triggers both immune signaling and degradation of the internalized pathogen. The discovery of this pathway reveals that cells possess an early warning system of invasion that works against a diverse array of pathogens and does not require recognition of any specific pathogen molecules. Science , this issue 10.1126/science.1256070

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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