HIV Proviral Burden, Genetic Diversity, and Dynamics in Viremic Controllers Who Subsequently Initiated Suppressive Antiretroviral Therapy-Reference-Cited by-同舟云学术

HIV Proviral Burden, Genetic Diversity, and Dynamics in Viremic Controllers Who Subsequently Initiated Suppressive Antiretroviral Therapy

Published:2021-12-21 Issue:6 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Omondi F. Harrison¹²^ORCID,Sudderuddin Hanwei²,Shahid Aniqa¹²,Kinloch Natalie N.¹²,Jones Bradley R.²³,Miller Rachel L.²³,Tsai Olivia¹,MacMillan Daniel²,Trocha Alicja⁴,Brockman Mark A.¹⁵^ORCID,Brumme Chanson J.²⁶,Joy Jeffrey B.²³⁶,Liang Richard²,Walker Bruce D.⁴,Brumme Zabrina L.¹²^ORCID

Affiliation:

1. Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada

2. British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada

3. Bioinformatics Program, University of British Columbia, Vancouver, British Columbia, Canada

4. Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA

5. Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada

6. Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada

Abstract

HIV therapy is lifelong because integrated, replication-competent viral copies persist within long-lived cells. To cure HIV, we need to understand when these viral reservoirs form, how large and genetically diverse they are, and how long they endure.

Funder

Gouvernement du Canada | Canadian Institutes of Health Research

HHS | National Institutes of Health

Sub-Saharan African Network in TB/HIV research Excellence; DELTAS Africa Initiative

Canadian Institutes of Health Research Doctoral Award

Canadian Institutes of Health Research Vanier Doctoral Award

Canadian Institutes of Health Research MSc Award

HHS | NIH | National Institute of Allergy and Infectious Diseases

Michael Smith Foundation for Health Research

Publisher

American Society for Microbiology

Subject