Affiliation:
1. Department of Microbial Pathogenesis, School of Dentistry, University of Maryland and Institute of Marine and Environmental Technology, Baltimore, Maryland, USA
Abstract
β-Lactam resistance in
Staphylococcus aureus
limits treatment options. Stp1 and Stk1, a serine-threonine phosphatase and kinase, respectively, mediate serine-threonine kinase (STK) signaling. Loss-of-function point mutations in
stp1
were detected among laboratory-passaged β-lactam-resistant
S. aureus
strains lacking
mecA
and
blaZ
, the major determinants of β-lactam resistance in the bacteria.
Funder
HHS | NIH | National Institute of Allergy and Infectious Diseases
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
8 articles.
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