FANCD2 Binding to H4K20me2 via a Methyl-Binding Domain Is Essential for Efficient DNA Cross-Link Repair-Reference-Cited by-同舟云学术

FANCD2 Binding to H4K20me2 via a Methyl-Binding Domain Is Essential for Efficient DNA Cross-Link Repair

Published:2019-08 Issue:15 Volume:39 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Paquin Karissa L.¹,Mamrak Nicholas E.¹,Garzon Jada L.¹,Cantres-Velez Juan A.¹,Azzinaro Paul A.¹,Vuono Elizabeth A.¹,Lima Kevin E.¹,Camberg Jodi L.¹,Howlett Niall G.¹^ORCID

Affiliation:

1. Department of Cell and Molecular Biology, University of Rhode Island, Kingston, Rhode Island, USA

Abstract

Fanconi anemia (FA) is an inherited disease characterized by bone marrow failure and increased cancer risk. FA is caused by mutation of any 1 of 22 genes, and the FA proteins function cooperatively to repair DNA interstrand cross-links (ICLs). A central step in the activation of the FA pathway is the monoubiquitination of the FANCD2 and FANCI proteins, which occurs within chromatin. How FANCD2 and FANCI are anchored to chromatin remains unknown.

Funder

NIH/NIGMS

NSF

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00194-19

Reference67 articles.

1. Structural Basis for the Methylation State-Specific Recognition of Histone H4-K20 by 53BP1 and Crb2 in DNA Repair

2. Methylation of Histone H4 Lysine 20 Controls Recruitment of Crb2 to Sites of DNA Damage