GRWD1-WDR5-MLL2 Epigenetic Complex Mediates H3K4me3 Mark and Is Essential for Kaposi’s Sarcoma-Associated Herpesvirus-Induced Cellular Transformation-Reference-Cited by-同舟云学术

GRWD1-WDR5-MLL2 Epigenetic Complex Mediates H3K4me3 Mark and Is Essential for Kaposi’s Sarcoma-Associated Herpesvirus-Induced Cellular Transformation

Published:2021-12-21 Issue:6 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Wei Shan¹,Lu Songjian²,Liang Lifan²,Wang Xian¹,Li Wan¹,Li Tingting¹,Chen Luping¹,Ju Enguo¹,Zhang Xinquan¹,Lai Zhao³,Huang Yufei¹⁴,Lu Xinghua²,Gao Shou-Jiang¹

Affiliation:

1. Cancer Virology Program, UPMC Hillman Cancer Center, and Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

2. Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

3. Greehey Children’s Cancer Research Institute and Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA

4. Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Abstract

By performing a genome-wide CRISPR-Cas9 screening, we have identified cellular epigenetic regulators that are essential for KSHV-induced cellular transformation. Among them, GRWD1 regulates epigenetic active mark H3K4me3 by interacting with WDR5 and MLL2 and recruiting them to chromatin loci of specific genes in KSHV-transformed cells.

Funder

HHS | NIH | National Cancer Institute

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | National Institutes of Health

Cancer Prevention and Research Institute of Texas

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03431-21

Reference65 articles.