Kinetic Driver of Antibacterial Drugs against Plasmodium falciparum and Implications for Clinical Dosing-Reference-Cited by-同舟云学术

Kinetic Driver of Antibacterial Drugs against Plasmodium falciparum and Implications for Clinical Dosing

Published:2019-11 Issue:11 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Caton Emily¹,Nenortas Elizabeth¹,Bakshi Rahul P.¹²,Shapiro Theresa A.¹²

Affiliation:

1. Division of Clinical Pharmacology, Departments of Medicine and of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

2. The Johns Hopkins Malaria Research Institute, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA

Abstract

Antibacterial drugs are an important component of malaria therapy. We studied the interactions of clindamycin, tetracycline, chloramphenicol, and ciprofloxacin against Plasmodium falciparum under static and dynamic conditions. In microtiter plate assays (static conditions), and as expected, parasites displayed the delayed death response characteristic for apicoplast-targeting drugs.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Bloomberg Family Foundation

Johns Hopkins Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00416-19

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