Inhibitory Compounds Targeting Plasmodium falciparum Gyrase B

Author:

Pakosz Zuzanna12,Lin Ting-Yu3,Michalczyk Elizabeth14,Nagano Soshichiro3,Heddle Jonathan Gardiner13ORCID

Affiliation:

1. Malopolska Centre of Biotechnology, Krakow, Poland

2. Postgraduate School of Molecular Medicine, Medical University of Warsaw, Warsaw, Poland

3. Heddle Initiative Research Unit, RIKEN, Wako, Saitama, Japan

4. Department of Cell Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland

Abstract

Malaria persists as a major health problem due to the spread of drug resistance and the lack of effective vaccines. DNA gyrase is a well-validated and extremely effective therapeutic target in bacteria, and it is also known to be present in the apicoplast of malarial species, including Plasmodium falciparum . This raises the possibility that it could be a useful target for novel antimalarials.

Funder

National Science Centre

MEXT | RIKEN

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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