Conformations of Human Immunodeficiency Virus Envelope Glycoproteins in Detergents and Styrene-Maleic Acid Lipid Particles

Author:

Zhou Rong12,Zhang Shijian12,Nguyen Hanh T.12ORCID,Ding Haitao34,Gaffney Althea5,Kappes John C.34,Smith Amos B.5,Sodroski Joseph G.12ORCID

Affiliation:

1. Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA

2. Department of Microbiology, Harvard Medical School, Boston, Massachusetts, USA

3. Department of Medicine, University of Alabama at Birmingham, Alabama, USA

4. Birmingham Veterans Affairs Medical Center, Research Service, Birmingham, Alabama, USA

5. Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, USA

Abstract

The human immunodeficiency virus (HIV) envelope glycoproteins (Envs) in the viral membrane mediate virus entry into the host cell and are targeted by neutralizing antibodies elicited by natural infection or vaccines. Detailed studies of membrane proteins rely on purification procedures that allow the proteins to maintain their natural conformation.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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