Conformations of Human Immunodeficiency Virus Envelope Glycoproteins in Detergents and Styrene-Maleic Acid Lipid Particles-Reference-Cited by-同舟云学术

Conformations of Human Immunodeficiency Virus Envelope Glycoproteins in Detergents and Styrene-Maleic Acid Lipid Particles

Published:2023-06-29 Issue:6 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Zhou Rong¹²,Zhang Shijian¹²,Nguyen Hanh T.¹²^ORCID,Ding Haitao³⁴,Gaffney Althea⁵,Kappes John C.³⁴,Smith Amos B.⁵,Sodroski Joseph G.¹²^ORCID

Affiliation:

1. Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA

2. Department of Microbiology, Harvard Medical School, Boston, Massachusetts, USA

3. Department of Medicine, University of Alabama at Birmingham, Alabama, USA

4. Birmingham Veterans Affairs Medical Center, Research Service, Birmingham, Alabama, USA

5. Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, USA

Abstract

The human immunodeficiency virus (HIV) envelope glycoproteins (Envs) in the viral membrane mediate virus entry into the host cell and are targeted by neutralizing antibodies elicited by natural infection or vaccines. Detailed studies of membrane proteins rely on purification procedures that allow the proteins to maintain their natural conformation.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00327-23

Reference102 articles.

1. The HIV-1 Envelope Glycoproteins: Fusogens, Antigens, and Immunogens

2. Molecular Mechanism of HIV-1 Entry

3. Viral membrane fusion