The HIV-1 Envelope Glycoproteins: Fusogens, Antigens, and Immunogens-Reference-Cited by-同舟云学术

The HIV-1 Envelope Glycoproteins: Fusogens, Antigens, and Immunogens

Published:1998-06-19 Issue:5371 Volume:280 Page:1884-1888
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Wyatt Richard¹,Sodroski Joseph¹

Affiliation:

1. R. Wyatt is in the Department of Cancer Immunology/AIDS, Dana-Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, MA 02115, USA. J. Sodroski is in the Department of Cancer Immunology/AIDS, Dana-Farber Cancer Institute, Department of Pathology, Harvard Medical School, and Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA.

Abstract

The human immunodeficiency virus–type 1 (HIV-1) envelope glycoproteins interact with receptors on the target cell and mediate virus entry by fusing the viral and cell membranes. The structure of the envelope glycoproteins has evolved to fulfill these functions while evading the neutralizing antibody response. An understanding of the viral strategies for immune evasion should guide attempts to improve the immunogenicity of the HIV-1 envelope glycoproteins and, ultimately, aid in HIV-1 vaccine development.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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