Analysis of Staphylococcus aureus Transcriptome in Pediatric Soft Tissue Abscesses and Comparison to Murine Infections-Reference-Cited by-同舟云学术

Analysis of Staphylococcus aureus Transcriptome in Pediatric Soft Tissue Abscesses and Comparison to Murine Infections

Published:2021-03-17 Issue:4 Volume:89 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Moffitt K.¹²,Cheung E.¹,Yeung T.¹,Stamoulis C.³²,Malley R.¹²

Affiliation:

1. Division of Infectious Diseases, Boston Children’s Hospital, Boston, Massachusetts, USA

2. Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA

3. Division of Adolescent Medicine, Boston Children’s Hospital, Boston, Massachusetts, USA

Abstract

A comprehensive understanding of how Staphylococcus aureus adapts to cause infections in humans can inform development of diagnostic, therapeutic, and preventive approaches. Expression analysis of clinical strain libraries depicts in vitro conditions that differ from those in human infection, but low bacterial burden and the requirement for reverse transcription or nucleic acid amplification complicate such analyses of bacteria causing human infection.

Funder

Boston Children's Hospital Translational Research Center

HHS | NIH | National Center for Advancing Translational Sciences

Harvard Catalyst

Charles H. Hood Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00715-20

Reference52 articles.