Targeted Transcriptomic Screen of Pneumococcal Genes Expressed during Murine and Human Infection-Reference-Cited by-同舟云学术

Targeted Transcriptomic Screen of Pneumococcal Genes Expressed during Murine and Human Infection

Published:2022-07-21 Issue:7 Volume:90 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Basset Alan¹,Wall Emma²³,Mitsi Elena⁴,Deshusses Chloe¹,Daly Raecliffe¹,Pojar Sherin⁴,Reiné Jesús⁴,Guerra-Assuncao Jose Afonso²,Denis Brigitte⁵,Jochems Simon P.⁴,Heyderman Robert²,Brown Jeremy²,Lu Ying-Jie¹,Ferreira Daniela M.⁴,Malley Richard¹^ORCID

Affiliation:

1. Division of Infectious Diseases, Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

2. Research Division of Infection, University College London, London, United Kingdom

3. Francis Crick Institute, London, United Kingdom

4. Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

5. Malawi Liverpool Wellcome Trust, Blantyre, Malawi

Abstract

The advent of pneumococcal conjugate vaccines led to the near disappearance of most of the included serotypes in high-income settings but also the rise of nonvaccine-type colonization and disease. Alternative strategies, using genetically conserved proteins as antigens, have been evaluated preclinically and clinically for years, so far unsuccessfully.

Funder

Translational Research Program, Boston Children's Hospital

Francis Crick Institute

Global Challenges Research Fund

Wellcome Trust

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.00175-22

Reference38 articles.