Affiliation:
1. Eastern Regional Research Center, Agricultural Research, Science and Education Administration, U.S. Department of Agriculture, Philadelphia, Pennsylvania 19118
Abstract
Twelve straight-chain esters, C
5
to C
14
, C
16
, and C
18
, of
p
-hydroxybenzoic acid were prepared, and their melting points, solubilities in water at 25°C, infrared spectra, dissociation constants (
pK
a
), and activities against
Clostridium botulinum
were determined. These studies also included four commercial straight-chain esters, C
1
to C
4
. The most potent activity was exhibited by undecyl and dodecyl esters, which are about 300 times as active as sodium nitrite. Quadratic and cubic equations were developed correlating the activity with
pK
a
values and chain length of the esters, respectively.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
37 articles.
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