The Combinations Chitosan-Pam 3 CSK 4 and Chitosan-Monophosphoryl Lipid A: Promising Immune-Enhancing Adjuvants for Anticaries Vaccine PAc-Reference-Cited by-同舟云学术

The Combinations Chitosan-Pam 3 CSK 4 and Chitosan-Monophosphoryl Lipid A: Promising Immune-Enhancing Adjuvants for Anticaries Vaccine PAc

Published:2019-12 Issue:12 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Bi Yongli¹,Xu Qingan²³,Su Lingkai⁴,Xu Jiantao⁵,Liu Zhongfang¹,Yang Ying¹,Tang Hua⁶,Li Yuhong¹,Fan Mingwen¹

Affiliation:

1. The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory for Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China

2. School of Medicine, Jianghan University, Wuhan, China

3. Wuhan First Stomatological Hospital, Wuhan, China

4. Department of Endodontics and Key Laboratory for Oral Biomedical Research of Zhejiang Province, Affiliated Hospital of Stomatology, Medical College, Zhejiang University, Hangzhou, China

5. Taikang Tongji (Wuhan) Hospital, Wuhan, China

6. Institute of Immunology, Taishan Medical University, Taian, China

Abstract

We previously demonstrated that recombinant protein PAc could be administered as an anticaries vaccine. However, the relatively weak immunogenicity of PAc limits its application. In the present study, we investigated the effect of two adjuvant combinations of chitosan plus Pam 3 CSK 4 (chitosan-Pam 3 CSK 4 ) and of chitosan plus monophosphoryl lipid A (chitosan-MPL) in the immune responses to the PAc protein in vivo and in vitro .

Funder

Wuhan University

Jianghan University

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00651-19

Reference37 articles.

1. Molecular characterization of a surface protein antigen gene from serotype c Streptococcus mutans, implicated in dental caries

2. Interaction between surface protein antigens of Streptococcus mutans and human salivary components