A Nanoparticle-Based Anticaries Vaccine Enhances the Persistent Immune Response To Inhibit Streptococcus mutans and Prevent Caries-Reference-Cited by-同舟云学术

A Nanoparticle-Based Anticaries Vaccine Enhances the Persistent Immune Response To Inhibit Streptococcus mutans and Prevent Caries

Published:2023-04-13 Issue:2 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Yu You-Bo¹²,Liu Ying²,Liang Hangeri²,Dong Xianxin³,Yang Xiao-Yan²^ORCID,Li Sha²,Guo Zhong¹

Affiliation:

1. Center for Biological Science and Technology, Advanced Institute of Natural Sciences, Beijing Normal University, Zhuhai, Guangdong, China

2. Zhuhai Key Laboratory of Basic and Applied Research in Chinese Medicine, College of Bioengineering, Zhuhai Campus of Zunyi Medical University, Zhuhai, Guangdong, China

3. Instrumentation and Service Center for Science and Technology, Beijing Normal University, Zhuhai, Guangdong, China

Abstract

Streptococcus mutans is the main etiologic bacterium of dental caries, whose protein antigen c (PAc) has been administered as an anticaries vaccine. However, the immunogenicity of PAc is relatively weak.

Funder

National Natural Science Foundation of China

Beijing Normal University

Natural Science Foundation of Guizhou Province

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.04328-22

Reference33 articles.

1. Global Burden of Untreated Caries

2. Oral diseases: a global public health challenge

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4. Investigating the candidacy of the serotype specific rhamnan polysaccharide based glycoconjugates to prevent disease caused by the dental pathogen Streptococcus mutans

5. A Caries Vaccine?