Congo red inhibition of scrapie agent replication-Reference-Cited by-同舟云学术

Congo red inhibition of scrapie agent replication

Published:1993-10 Issue:10 Volume:67 Page:6270-6272
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Caughey B¹,Ernst D¹,Race R E¹

Affiliation:

1. Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840.

Abstract

Congo red inhibits the accumulation of protease-resistant PrP in scrapie-infected mouse neuroblastoma cells. Here we show that Congo red also inhibits the replication of scrapie infectivity in these cells. This observation is consistent with the idea that protease-resistant PrP is a vital component of the scrapie agent or that agent replication depends on the presence of protease-resistant PrP in the cell.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.67.10.6270-6272.1993

Reference24 articles.

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4. Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells;Caughey B.;J. Virol.,1993

5. Identification of scrapie prion protein-specific mRNA in scrapie-infected and uninfected brain;Chesebro B.;Nature (London),1985

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