In Vitro Susceptibility of Neisseria gonorrhoeae Strains to Mupirocin, an Antibiotic Reformulated for Parenteral Administration in Nanoliposomes

Author:

Cern Ahuva1,Connolly Kristie L.2,Jerse Ann E.2,Barenholz Yechezkel1

Affiliation:

1. Laboratory of Membrane and Liposome Research, Department of Biochemistry, IMRIC, The Hebrew University, Hadassah Medical School, Jerusalem, Israel

2. Department of Microbiology and Immunology, F. Edward Hèbert School of Medicine, Uniformed Services University, Bethesda, Maryland, USA

Abstract

ABSTRACT Neisseria gonorrhoeae is an urgent antibiotic-resistant threat. This study determined the MICs of mupirocin to be 0.0039 to 0.0625 μg/ml for 94 N. gonorrhoeae strains. Cross-resistance with other antibiotics was not detected. Mupirocin, which is currently limited to topical administration, demonstrated activity by injection when delivered in nanoliposomes. The nanoliposomal formulation of mupirocin is a potential treatment for drug-resistant N. gonorrhoeae .

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference11 articles.

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2. U.S. Department of Health and Human Services, Centers for Disease Control and Prevention. 2013. Antibiotic resistance threats in the United States, 2013. Centers for Disease Control and Prevention, Atlanta, GA. https://www.cdc.gov/drugresistance/pdf/ar-threats-2013-508.pdf.

3. Antimicrobial resistance in Neisseria gonorrhoeae: Global surveillance and a call for international collaborative action

4. Interaction of pseudomonic acid A with Escherichia coli B isoleucyl-tRNA synthetase

5. The clinical development of mupirocin

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