Formulation and Characterization of Mupirocin Nanomicelles in Insulin-Based Gel for Dermatological Application-Reference-Cited by-同舟云学术

Formulation and Characterization of Mupirocin Nanomicelles in Insulin-Based Gel for Dermatological Application

Published:2023-07 Issue:Suppl 2 Volume:15 Page:S1178-S1181
ISSN:0976-4879
Container-title:Journal of Pharmacy and Bioallied Sciences
language:en
Short-container-title:

Author:

Zubairi Maysaa B.¹,Abd Abdulkareem H.²,Al-lami Mohammed S.³

Affiliation:

1. Department of Pharmacology and Toxicology, College of Pharmacy, University of Basra, Basra, Iraq

2. Department of Pharmacology, College of Medicine, Al-Nahrain University, Baghdad, Iraq

3. Department of Pharmaceutics, College of Pharmacy, University of Basra, Basra, Iraq

Abstract

ABSTRACT Aim: To produce and analyze mupirocin nanomicelle (MP-NM) in insulin-based gel. Procedures: MP-NM was prepared using solvent evaporation with Tween 80 as a surfactant. HPMC polymer prepared gel. MP-NM was characterized by globular diameter, polydispersity index (PDI), pH, entrapment efficiency (EE), and transmission electron microscopy (TEM). NM MP release was studied in vitro. Results: The revolutionary MP-NM in insulin-based gel dissolves MP completely without precipitation due to its unique physical and chemical properties. MP had 8.64 ± 0.2 nm globular diameter, high EE (98.85 ± 0.01%), and normal homogeneous dispersion (PDI, 0.143 ± 0.003) in NM. MP’s formula showed rapid first-order kinetics release. Conclusion: To our knowledge, this is the first MP-NM nano-drug delivery system employing insulin-based gel. It has promising pre-clinical and clinical uses.

Publisher

Medknow

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,Bioengineering,General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,Bioengineering

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