Fluoroquinolone Resistance in Mycobacterium tuberculosis and Mutations in gyrA and gyrB-Reference-Cited by-同舟云学术

Fluoroquinolone Resistance in Mycobacterium tuberculosis and Mutations in gyrA and gyrB

Published:2009-10 Issue:10 Volume:53 Page:4498-4500
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Von Groll Andrea¹,Martin Anandi¹,Jureen Pontus²,Hoffner Sven²,Vandamme Peter³,Portaels Françoise¹,Palomino Juan Carlos¹,da Silva Pedro Almeida⁴

Affiliation:

1. Mycobacteriology Unit, Institute of Tropical Medicine, Antwerp, Belgium

2. Laboratory of Tuberculosis, Department of Bacteriology, Swedish Institute for Infectious Disease Control, Solna, Sweden

3. Laboratory of Microbiology, Ghent University, Ghent, Belgium

4. Laboratory of Mycobacteriology, Universidade Federal do Rio Grande (FURG), Rio Grande, Brazil

Abstract

ABSTRACT This study evaluated cross-resistance of Mycobacterium tuberculosis strains to ofloxacin, moxifloxacin, and gatifloxacin and investigated the presence of mutations in gyrA and gyrB . Fluoroquinolone susceptibilities were determined for 41 M. tuberculosis strains by the proportion method on 7H11, and MICs were determined by the resazurin microtiter assay. Forty strains shared the same resistance results for the three fluoroquinolones. However, one strain, with an Asn-533 → Thr mutation in gyrB , was susceptible to ofloxacin but resistant to moxifloxacin and gatifloxacin.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00287-09

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