In Vitro and In Vivo Activities of Gatifloxacin against Mycobacterium tuberculosis-Reference-Cited by-同舟云学术

In Vitro and In Vivo Activities of Gatifloxacin against Mycobacterium tuberculosis

Published:2002-04 Issue:4 Volume:46 Page:1022-1025
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Alvirez-Freites Enrique J.¹,Carter Janna L.²,Cynamon Michael H.¹²

Affiliation:

1. Department of Microbiology and Immunology, Upstate Medical University, State University of New York

2. Department of Medicine, Veterans Affairs Medical Center, Syracuse, New York

Abstract

ABSTRACT Gatifloxacin (GAT) and moxifloxacin (MXF) were evaluated in vitro to determine their activities against Mycobacterium tuberculosis . GAT was subsequently compared in a dose range study to isoniazid (INH) in a murine tuberculosis model. GAT was somewhat less active than INH. GAT and MXF were evaluated in mice infected with M. tuberculosis and were found to have similar activities. GAT was studied alone and in combination with ethambutol, ethionamide (ETA), and pyrazinamide (PZA) and compared to INH and rifampin (RIF). GAT appears to have sufficient activity alone and in combination with ETA with or without PZA to merit evaluation for treatment of tuberculosis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.46.4.1022-1025.2002

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