Mycobacterium tuberculosis Toxin CpnT Is an ESX-5 Substrate and Requires Three Type VII Secretion Systems for Intracellular Secretion-Reference-Cited by-同舟云学术

Mycobacterium tuberculosis Toxin CpnT Is an ESX-5 Substrate and Requires Three Type VII Secretion Systems for Intracellular Secretion

Published:2021-04-27 Issue:2 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Izquierdo Lafuente B.¹,Ummels R.²,Kuijl C.²^ORCID,Bitter W.¹²,Speer A.²^ORCID

Affiliation:

1. Section of Molecular Microbiology, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

2. Department of Medical Microbiology and Infection Control, Amsterdam UMC, Location VU Medical Center, Amsterdam, The Netherlands

Abstract

CpnT, a NAD + glycohydrolase, is the only known toxin that is secreted by Mycobacterium tuberculosis . CpnT is composed of two domains; the C-terminal domain is the toxin, whereas the N-terminal domain is required for secretion.

Funder

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02983-20

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