Heterogeneous Genetic Location of mcr-1 in Colistin-Resistant Escherichia coli Isolates from Humans and Retail Chicken Meat in Switzerland: Emergence of mcr-1 -Carrying IncK2 Plasmids-Reference-Cited by-同舟云学术

Heterogeneous Genetic Location of mcr-1 in Colistin-Resistant Escherichia coli Isolates from Humans and Retail Chicken Meat in Switzerland: Emergence of mcr-1 -Carrying IncK2 Plasmids

Published:2017-11 Issue:11 Volume:61 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Donà Valentina¹,Bernasconi Odette J.¹²,Pires João¹²,Collaud Alexandra³,Overesch Gudrun³,Ramette Alban¹,Perreten Vincent³^ORCID,Endimiani Andrea¹^ORCID

Affiliation:

1. Institute for Infectious Diseases, University of Bern, Bern, Switzerland

2. Graduate School of Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland

3. Institute of Veterinary Bacteriology, Vetsuisse Faculty, University of Bern, Bern, Switzerland

Abstract

ABSTRACT We characterized the genetic environment of mcr-1 in colistin-resistant Escherichia coli strains isolated in Switzerland during 2014 to 2016 from humans ( n = 3) and chicken meat ( n = 6). Whole-genome and plasmid sequencing identified the mcr-1 gene integrated in IncX4 (of which, one strain carried the mcr-1.2 variant), IncI2, IncHI2, and novel IncK2 plasmids (overall, n = 7), as well as in the bacterial chromosome ( n = 2) in single or duplicate copies. Our study supports the easy mobilization of mcr-1 across diverse genetic locations.

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01245-17

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