Production of the Monamycins, Novel Depsipeptide Antibiotics

Author:

Hall M. J.1,Hassall C. H.1

Affiliation:

1. Department of Chemistry, University College of Swansea, Swansea, Wales, United Kingdom

Abstract

Methods are described for the production of the monamycins by Streptomyces jamaicensis in shake flasks and jar fermentors. The effects on the fermentation of variations in p H, temperature, medium composition, volume of inoculum, and strain of the organism are discussed. The methods employed for the extraction and for the microbiological assay of the antibiotics are outlined.

Publisher

American Society for Microbiology

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

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