Activities of Moxifloxacin Alone and in Combination with Other Antimicrobial Agents against Multidrug-Resistant Mycobacterium tuberculosis Infection in BALB/c Mice

Author:

Fattorini Lanfranco1,Tan Dejiang1,Iona Elisabetta1,Mattei Maurizio2,Giannoni Federico1,Brunori Lara1,Recchia Simona1,Orefici Graziella1

Affiliation:

1. Laboratory of Bacteriology and Medical Mycology, Istituto Superiore di Sanità

2. STA, Department of Biology, University of “Tor Vergata,” Rome, Italy

Abstract

ABSTRACT The activity of moxifloxacin was enhanced by the addition of ethionamide but not by that of cycloserine, thiacetazone, capreomycin, para -aminosalicylic acid, or linezolid in BALB/c mice infected with a strain of Mycobacterium tuberculosis resistant to isoniazid, rifampin, and six other drugs. These observations are important for the therapy of multidrug-resistant tuberculosis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference18 articles.

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3. Activities of Several Novel Oxazolidinones against Mycobacterium tuberculosis in a Murine Model

4. Fattorini, L., E. Iona, M. L. Ricci, O. F. Thoresen, G. Orrù, M. R. Oggioni, E. Tortoli, C. Piersimoni, P. Chiaradonna, M. Tronci, G. Pozzi, and G. Orefici. 1999. Activity of 16 antimicrobial agents against drug-resistant strains of Mycobacterium tuberculosis. Microb. Drug Resist.5:265-270.

5. Heifets L. B. 1991. Antituberculous drugs: activity in vitro p. 13-57. In L. B. Heifets (ed.) Drug susceptibilities in the chemotherapy of mycobacterial infections. CRC Press Inc. Boca Raton Fla.

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