Affiliation:
1. Virginia Commonwealth University, Richmond
2. Focus Technologies, Herndon, Virginia
Abstract
ABSTRACT
Access to current antimicrobial agent surveillance data is an important prerequisite for the optimal management of patients with hospital-acquired infections. The present study used data collected in 2000 to 2001 from 670 laboratories in Europe (France, Germany, Italy, and Spain), Canada, and the United States to report on the in vitro activities of ceftriaxone, cefotaxime, and comparative agents against >125,000 isolates of gram-negative bacteria from hospitalized patients. All but two isolates of
Enterobacteriaceae
(one isolate of
Proteus mirabilis
from France and one isolate of
Morganella morganii
from Canada) were susceptible to imipenem. The susceptibility of
Escherichia coli
to ceftriaxone or cefotaxime was ≥97% in each country, and for
P. mirabilis
, susceptibility was 99% in each country except Italy. In contrast, susceptibility of
E. coli
to ciprofloxacin varied from 80.5% (Spain) to 94.0% (France); levofloxacin susceptibility ranged from 75.2% (Spain) to 91.6% (United States). Among
Klebsiella pneumoniae
and
Klebsiella oxytoca
isolates, ceftriaxone and cefotaxime susceptibilities ranged from 86.6 to 98.7% and 83.5 to 99.7%, respectively, depending upon the country. Considerable geographic variation in the susceptibilities (generally 85 to 95% susceptible) of
Serratia marcescens
and
M. morganii
to ceftriaxone and cefotaxime were observed. For
S. marcescens
, susceptibility to piperacillin-tazobactam varied from 81.5% (France) to 94.1% (Italy) and susceptibility to ciprofloxacin ranged from 66.2% (Germany) to 90.7% (Spain).
Enterobacter cloacae
and
Enterobacter aerogenes
were less susceptible to ceftriaxone and cefotaxime than were the other species of
Enterobacteriaceae
studied. The present study demonstrated that established parenteral expanded-spectrum cephalosporin antimicrobial agents retain significant in vitro activity against many clinically important gram-negative pathogens.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
38 articles.
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