Abstract
Abstract
Background
The nightmare of the rising numbers of multidrug-resistant organisms (MDROs) requires the implementation of effective stewardship programs. However, this should be preceeded by making available evidence-based knowledge regarding the local antimicrobial resistance pattern, which is fundamental. The aim of the current study is to determine the prevalence of MDRO among different Ain Shams University Hospitals (ASUHs) intensive care units (ICUs) and detect the resistance profile of the common pathogens.
Results
The 1-year records of a total of 1280 pathogens were studied. The highest number of pathogens were isolated from blood cultures (44.84%), followed by urine (41.41%) then wound swabs (13.75%). Gram-negative isolates (57.5%) were more prevalent than gram-positive ones (31.1%). The most frequently isolated pathogens were Klebsiella spp. (22.5%), Escherichia coli (13.4%), and Coagulase-negative Staphylococci (12.5%). The highest percentage of resistance among gram-positive organisms was exhibited by penicillin (89.5%) followed by erythromycin (83.98%) and then cefoxitin (76.52%). None of the isolates showed resistance to linezolid and resistance to vancomycin was minimal (2.62%). Gram-negative isolates exhibited high overall resistance to all used antibiotic classes. The least frequency of resistance was recorded against nitrofurantoin (52.5%), amikacin (58.01%), followed by imipenem (59.78%) and meropenem (61.82%). All isolates of Pseudomonas and Acinetobacter showed 100% susceptibility to colistin.
Conclusions
The prevalence of antibiotic resistance in Ain Shams University Hospitals (ASUHs) was high among both gram-negative and gram-positive organisms. This high resistance pattern foreshadows an inevitable catastrophe that requires continuous monitoring and implementation of effective antibiotic stewardship.
Publisher
Springer Science and Business Media LLC
Reference39 articles.
1. Oduyebo OO, Olayinka AT, Iregbu KC, Versporten A, Goossens H, Nwajiobi-Princewill PI, et al. A point prevalence survey of antimicrobial prescribing in four Nigerian tertiary hospitals. Ann Trop Pathol. 2017;8:42–6. http://www.atpjournal.org/text.asp?2017/8/1/42/224161.
2. Simmons BP, Larson EL. Multiple drug resistant organisms in healthcare: the failure of contact precautions. J Infect Prev. 2015;16(4):178–81.
3. Shebl RI, Mosaad YO. Frequency and antimicrobial resistance pattern among bacterial clinical isolates recovered from different specimens in Egypt. Cent African J Public Heal. 2019;5(1):36–45.
4. Zhi-Wen Y, Yan-Li Z, Man Y, Wei-Jun F. Clinical treatment of pandrug-resistant bacterial infection consulted by clinical pharmacist. Saudi Pharm J. 2015;23(4):377–80.
5. Centers for Disease Control and Prevention. Antibiotic resistance threats in the United States. Atlanta: U.S. Department of health and human services, CDC; 2019. https://www.cdc.gov/drugresistance/biggest-threats.html.
Cited by
28 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献