MannosylGlycodendritic Structure Inhibits DC-SIGN-Mediated Ebola VirusInfection in cis and in trans-Reference-Cited by-同舟云学术

MannosylGlycodendritic Structure Inhibits DC-SIGN-Mediated Ebola VirusInfection in cis and in trans

Published:2003-12 Issue:12 Volume:47 Page:3970-3972
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Lasala Fátima¹,Arce Eva²,Otero Joaquín R.¹,Rojo Javier²,Delgado Rafael¹

Affiliation:

1. Laboratorio de Microbiología Molecular, Servicio de Microbiología, Hospital Universitario 12 de Octubre, Madrid

2. Grupo Carbohidratos, Instituto de Investigaciones Químicas, Consejo Superior de Investigaciones Centíficas, Seville,Spain

Abstract

ABSTRACT We have designed a glycodendritic structure, BH30sucMan, that blocks the interaction between dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) and Ebola virus (EBOV) envelope. BH30sucMan inhibits DC-SIGN-mediated EBOV infection at nanomolar concentrations. BH30sucMan may counteract important steps of the infective process of EBOV and, potentially, of microorganisms shown to exploit DC-SIGN for cell entry and infection.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.47.12.3970-3972.2003

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