Probing scaffold size effects on multivalent lectin–glycan binding affinity, thermodynamics and antiviral properties using polyvalent glycan-gold nanoparticles-Reference-Cited by-同舟云学术

Probing scaffold size effects on multivalent lectin–glycan binding affinity, thermodynamics and antiviral properties using polyvalent glycan-gold nanoparticles

Published:2024 Issue:29 Volume:16 Page:13962-13978
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Basaran Rahman¹,Budhadev Darshita¹,Kempf Amy²,Nehlmeier Inga²,Hondow Nicole³,Pöhlmann Stefan²⁴,Guo Yuan⁵^ORCID,Zhou Dejian¹^ORCID

Affiliation:

1. School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK

2. Infection Biology Unit, German Primate Centre - Leibniz Institute for Primate Research, 37077 Göttingen, Germany

3. School of Chemical and Process Engineering, University of Leeds, Leeds LS2 9JT, UK

4. Faculty of Biology and Psychology, Georg-August-University Göttingen, 37073 Göttingen, Germany

5. School of Food Science and Nutrition, and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK

Abstract

Increasing GNP-glycan's scaffold size impacts very differently for their ability to block DC-SIGN- from DC-SIGNR- promoted viral infection: enhancing only the potency in the former, but enhancing both the potency and cooperativity in the latter.

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/NR/D4NR00484A

Reference62 articles.

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