Implication of Broadly Neutralizing Bovine Monoclonal Antibodies in the Development of an Enzyme-Linked Immunosorbent Assay for Detecting Neutralizing Antibodies against Foot-and-Mouth Disease Virus Serotype O-Reference-Cited by-同舟云学术

Implication of Broadly Neutralizing Bovine Monoclonal Antibodies in the Development of an Enzyme-Linked Immunosorbent Assay for Detecting Neutralizing Antibodies against Foot-and-Mouth Disease Virus Serotype O

Published:2019-12 Issue:12 Volume:57 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Cao Yimei¹,Li Kun¹,Wang Sheng¹,Fu Yuanfang¹,Sun Pu¹,Li Pinghua¹,Bai Xingwen¹,Zhang Jing¹,Ma Xueqing¹,Xing Xiangchuan¹²,Zhou Shasha¹,Bao Huifang¹,Li Dong¹,Chen Yingli¹,Li Zhiyong¹,Lu Zengjun¹,Liu Zaixin¹

Affiliation:

1. State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory of China, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

2. Tianjin Weite Biological Medicine Co., Ltd., Tianjin, China

Abstract

Vaccination with inactivated vaccines is still the main measure to control foot-and-mouth disease (FMD) in areas where the disease is endemic, and the level of neutralizing antibody in vaccinated animals is directly related to their protection against virus challenge. Currently, neutralizing antibody is mainly detected using the virus neutralization test (VNT) based on cell culture, which is laborious and time-consuming and requires restrictive biocontainment facilities.

Funder

the National Key Research and Development Program of China

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.01030-19

Reference28 articles.

1. The Pathogenesis of Foot-and-Mouth Disease II: Viral Pathways in Swine, Small Ruminants, and Wildlife; Myotropism, Chronic Syndromes, and Molecular Virus-Host Interactions

2. Relative risks of the uncontrollable (airborne) spread of FMD by different species

3. The economic impacts of foot and mouth disease – What are they, how big are they and where do they occur?