SbcCD-Mediated Processing of Covalent Gyrase-DNA Complex in Escherichia coli-Reference-Cited by-同舟云学术

SbcCD-Mediated Processing of Covalent Gyrase-DNA Complex in Escherichia coli

Published:2013-08-05 Issue:10 Volume:57 Page:5116-5119
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob. Agents Chemother.

Author:

Aedo Sandra,Tse-Dinh Yuk-Ching

Abstract

ABSTRACTQuinolones trap the covalent gyrase-DNA complex inEscherichia coli, leading to cell death. Processing activities for trapped covalent complex have not been characterized. A mutant strain lacking SbcCD nuclease activity was examined for both accumulation of gyrase-DNA complex and viability after quinolone treatment. Higher complex levels were found in ΔsbcCDcells than in wild-type cells after incubation with nalidixic acid and ciprofloxacin. However, SbcCD activity protected cells against the bactericidal action of nalidixic acid but not ciprofloxacin.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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