Exonuclease VII repairs quinolone-induced damage by resolving DNA gyrase cleavage complexes-Reference-Cited by-同舟云学术

Exonuclease VII repairs quinolone-induced damage by resolving DNA gyrase cleavage complexes

Published:2021-03-05 Issue:10 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Huang Shar-yin N.¹^ORCID,Michaels Stephanie A.¹,Mitchell Brianna B.¹,Majdalani Nadim²^ORCID,Vanden Broeck Arnaud³^ORCID,Canela Andres⁴^ORCID,Tse-Dinh Yuk-Ching⁵^ORCID,Lamour Valerie³^ORCID,Pommier Yves¹^ORCID

Affiliation:

1. Laboratory of Molecular Pharmacology, Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.

2. Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.

3. Integrated Structural Biology Department, IGBMC, UMR7104 CNRS, U1258 Inserm, University of Strasbourg, Illkirch 67404, France.

4. The Hakubi Center for Advanced Research, Radiation Biology Center, Graduate School of Biostudies, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.

5. Department of Chemistry and Biochemistry, Biomolecular Sciences Institute, Florida International University, Miami, FL 33199, USA.

Abstract

Exonuclease VII excises trapped DNA gyrase and provides a new strategy to overcome resistance to quinolones.

Funder

NIH Office of the Director

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference51 articles.

1. Fluoroquinolone interactions withMycobacterium tuberculosisgyrase: Enhancing drug activity against wild-type and resistant gyrase

2. DNA topoisomerase II, genotoxicity, and cancer