Affiliation:
1. Department of Developmental Therapeutics, The University of Texas M. D. Anderson Hospital and Tumor Institute, Houston, Texas 77025
Abstract
BB-K8, an aminoglycoside antibiotic which is a derivative of kanamycin, was tested in vitro against 466 clinical bacterial isolates. Over 90% of gram-negative bacilli, except
Proteus
spp., were inhibited by 3.12 μg of BB-K8 per ml. This antibiotic was consistently more active than kanamycin but less active than tobramycin or gentamicin. Unlike kanamycin, BB-K8 was active against
Pseudomonas aeruginosa
. Eleven of 19 isolates resistant to either gentamicin or tobramycin, or both, were susceptible to BB-K8.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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