Affiliation:
1. College of Physicians and Surgeons, Columbia University, New York, New York 10032
Abstract
Tobramycin is an aminoglycoside antibiotic which has excellent antibacterial activity against
Pseudomonas, Staphylococcus aureus
, and many members of the
Enterobacteriaceae
. Most strains of
Serratia, Providence, Streptococcus
, and
Diplococcus pneumoniae
were resistant to concentrations of tobramycin which could be achieved in man. Tobramycin was effective against certain
Pseudomonas
strains resistant to gentamicin. The growth medium used to determine the inhibitory level of tobramycin had a significant effect upon the minimal inhibitory concentration. Calcium and magnesium ions inhibited the bactericidal effect of tobramycin. Tobramycin and carbenicillin acted in a synergistic manner. Ethylenediaminetetraacetic acid did not act in a synergistic manner with tobramycin. Broth-dilution susceptibility tests and disc-diffusion tests in agar (10-μg discs) showed excellent correlation except with
Proteus
strains.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
72 articles.
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