GSK3732394: a Multi-specific Inhibitor of HIV Entry

Author:

Wensel David1,Sun Yongnian2,Davis Jonathan3,Li Zhufang1,Zhang Sharon1,McDonagh Thomas3,Langley David2,Mitchell Tracy3,Tabruyn Sebastien4,Nef Patrick4,Cockett Mark1,Krystal Mark1

Affiliation:

1. ViiV Healthcare, Branford, Connecticut, USA

2. Bristol-Myers Squibb, Wallingford, Connecticut, USA

3. Bristol-Myers Squibb, Waltham, Massachusetts, USA

4. TransCure bioServices, Archamps, France

Abstract

There continue to be significant unmet medical needs for patients with HIV-1 infection. One way to improve adherence and decrease the likelihood of drug-drug interactions in HIV-1-infected patients is through the development of long-acting biologic inhibitors. Building on a bi-specific inhibitor approach targeting CD4 and gp41, a tri-specific molecule was generated with three distinct antiviral activities. The linkage of these three biologic inhibitors creates synergy that offers a series of advantages to the molecule. The addition of human serum albumin to the tri-specific inhibitor could allow it to function as a long-acting self-administered treatment for patients with HIV infection. This molecule is currently in early clinical trials.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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