Protein LC-MS Tools for the Next Generation of Biotherapeutic Analyses from Preclinical and Clinical Serum-Reference-Cited by-同舟云学术

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Protein LC-MS Tools for the Next Generation of Biotherapeutic Analyses from Preclinical and Clinical Serum

Published:2023-07-21 Issue:9 Volume:34 Page:1837-1846
ISSN:1044-0305
Container-title:Journal of the American Society for Mass Spectrometry
language:en
Short-container-title:J. Am. Soc. Mass Spectrom.

Author:

Schneck Nicole A.¹,Mehl John T.²,Kellie John F.²^ORCID

Affiliation:

1. Analytical Development, GSK, 1250 S. Collegeville Rd., Collegeville, Pennsylvania 19426, United States

2. Bioanalysis, Immunogenicity & Biomarkers, GSK, 1250 S. Collegeville Rd., Collegeville, Pennsylvania 19426, United States

Publisher

American Chemical Society (ACS)

Subject

Spectroscopy,Structural Biology

Link

https://pubs.acs.org/doi/pdf/10.1021/jasms.3c00064

Reference29 articles.

1. Key elements of bioanalytical method validation for small molecules

2. Usefulness of monitoring free (unbound) concentrations of therapeutic drugs in patient management

3. Bioanalytical LC–MS/MS of protein-based biopharmaceuticals

4. Application and challenges in using LC–MS assays for absolute quantitative analysis of therapeutic proteins in drug discovery

5. Bioanalytical method validation considerations for LC–MS/MS assays of therapeutic proteins

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