Evolution of Antibodies to Native Trimeric Envelope and Their Fc-Dependent Functions in Untreated and Treated Primary HIV Infection-Reference-Cited by-同舟云学术

Evolution of Antibodies to Native Trimeric Envelope and Their Fc-Dependent Functions in Untreated and Treated Primary HIV Infection

Published:2021-11-23 Issue:24 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Nagel Lauren¹²³,Kant Sanket¹²³,Leeks Christopher¹²³,Routy Jean-Pierre¹³⁴⁵,Tremblay Cécile⁶⁷,Thomas Réjean⁸,Szabo Jason³⁵⁸,Côté Pierre⁹,Trottier Benoit⁹,LeBlanc Roger¹⁰,Rouleau Danielle⁷,Dupuy Franck P.¹³,Bernard Nicole F.¹²³⁵¹¹^ORCID,

Affiliation:

1. Research Institute of the McGill University Health Centre (RI-MUHC), Montreal, Quebec, Canada

2. Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada

3. Infectious Diseases, Immunology and Global Health Program, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada

4. Division of Hematology, McGill University Health Centre, Montreal, Quebec, Canada

5. Chronic Viral Illness Service, McGill University Health Centre, Montreal, Quebec, Canada

6. Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM), Montreal, Quebec, Canada

7. Department of Microbiology, Infectiology and Immunology, University of Montreal, Montreal, Quebec, Canada

8. Clinique Médicale l’Actuel, Montréal, Quebec, Canada

9. Clinique de Médecine Urbaine du Quartier Latin, Montréal, Quebec, Canada

10. Clinique Médicale Opus, Montréal, Quebec, Canada

11. Division of Clinical Immunology, McGill University Health Centre, Montreal, Quebec, Canada

Abstract

Closed-conformation envelope is expressed on the surface of HIV-infected cells. Antibodies targeting this conformation and that support FcDFs have the potential to control HIV.

Funder

FRQ | Fonds de Recherche du Québec - Santé

Gouvernement du Canada | Canadian Institutes of Health Research

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01625-21

Reference68 articles.

1. Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand

2. Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial

3. Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG

4. Vaccine-Induced Env V1-V2 IgG3 Correlates with Lower HIV-1 Infection Risk and Declines Soon After Vaccination

5. Polyfunctional Fc-Effector Profiles Mediated by IgG Subclass Selection Distinguish RV144 and VAX003 Vaccines

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