Vaccine-Induced Env V1-V2 IgG3 Correlates with Lower HIV-1 Infection Risk and Declines Soon After Vaccination

Author:

Yates Nicole L.12,Liao Hua-Xin12,Fong Youyi3,deCamp Allan3,Vandergrift Nathan A.12,Williams William T.12,Alam S. Munir12,Ferrari Guido12,Yang Zhi-yong4,Seaton Kelly E.12,Berman Phillip W.5,Alpert Michael D.6,Evans David T.6,O’Connell Robert J.7,Francis Donald8,Sinangil Faruk8,Lee Carter8,Nitayaphan Sorachai9,Rerks-Ngarm Supachai10,Kaewkungwal Jaranit11,Pitisuttithum Punnee12,Tartaglia James13,Pinter Abraham14,Zolla-Pazner Susan15,Gilbert Peter B.3,Nabel Gary J.4,Michael Nelson L.16,Kim Jerome H.16,Montefiori David C.117,Haynes Barton F.1218,Tomaras Georgia D.1171819

Affiliation:

1. Duke Human Vaccine Institute, Durham, NC 27710, USA.

2. Department of Medicine, Duke University, Durham, NC 27710, USA.

3. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

4. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

5. Baskin School of Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.

6. Department of Microbiology and Immunology, Harvard Medical School, Boston MA 02115, USA.

7. Armed Forces Research Institute of Medical Sciences-US Component, Bangkok, Thailand.

8. Global Solutions for Infectious Diseases, South San Francisco, CA 94080, USA.

9. Armed Forces Research Institute of Medical Sciences-Royal Thai Army Component, Bangkok, Thailand.

10. Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand.

11. Center of Excellence for Biomedical and Public Health Informatics BIOPHICS, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

12. Mahidol University, Bangkok, Thailand.

13. Sanofi Pasteur, Swiftwater, PA 18370, USA.

14. New Jersey Medical School, Rutgers University, Newark, NJ 07103, USA.

15. Veterans Affairs Medical Center and New York University School of Medicine, New York, NY 10010, USA.

16. U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

17. Department of Surgery, Duke University, Durham, NC 27710, USA.

18. Department of Immunology, Duke University, Durham, NC 27710, USA.

19. Molecular Genetics and Microbiology, Duke University, Durham, NC 27710, USA.

Abstract

A V1-V2 IgG3 response to HIV correlates with a decreased risk of HIV-1 infection and is one vaccine-induced humoral response that is higher in a clinical trial showing HIV-1 vaccine efficacy compared to a trial showing nonefficacy.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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