Stabilizing the HIV-1 Envelope Glycoprotein State 2A Conformation-Reference-Cited by-同舟云学术

Stabilizing the HIV-1 Envelope Glycoprotein State 2A Conformation

Published:2021-02-10 Issue:5 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Vézina Dani¹²^ORCID,Gong Shang Yu¹³,Tolbert William D.⁴,Ding Shilei¹,Nguyen Dung⁴,Richard Jonathan¹²,Gendron-Lepage Gabrielle¹,Melillo Bruno⁵,Smith Amos B.⁵,Pazgier Marzena⁴,Finzi Andrés¹²³^ORCID

Affiliation:

1. Centre de Recherche du CHUM, Montreal, Quebec, Canada

2. Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, Quebec, Canada

3. Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada

4. Infectious Diseases Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

5. Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA

Abstract

Stabilization of HIV-1 Env state 2A has been shown to sensitize infected cells to ADCC. State 2A can be stabilized by a “cocktail” composed of CD4mc, anti-CoRBS, and anti-cluster A Abs.

Funder

HHS | National Institutes of Health

Gouvernement du Canada | Canadian Institutes of Health Research

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01620-20

Reference37 articles.

1. Human immunodeficiency virus type 1 gp120 envelope glycoprotein regions important for association with the gp41 transmembrane glycoprotein

2. Role of the gp120 inner domain β-sandwich in the interaction between the human immunodeficiency virus envelope glycoprotein subunits