Escherichia coli Constructs Expressing Human or Porcine Enterotoxins Induce Identical Diarrheal Diseases in a Piglet Infection Model-Reference-Cited by-同舟云学术

Escherichia coli Constructs Expressing Human or Porcine Enterotoxins Induce Identical Diarrheal Diseases in a Piglet Infection Model

Published:2008-09-15 Issue:18 Volume:74 Page:5832-5837
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Zhang Weiping¹,Robertson Donald C.²,Zhang Chengxian¹,Bai Wei¹,Zhao Mojun¹,Francis David H.¹

Affiliation:

1. The Center for Infectious Disease Research & Vaccinology, Department of Veterinary Science, South Dakota State University, Brookings, South Dakota

2. Department of Diagnostic Medicine Pathobiology, Kansas State University, Manhattan, Kansas

Abstract

ABSTRACT To develop a piglet model for studying diarrheal disease and developing vaccines, we challenged gnotobiotic piglets with isogenic Escherichia coli strains constructed to express porcine 987P(F6) fimbriae and a heat-labile or a heat-stable enterotoxin to examine clinical outcomes. Piglets developed identical diarrheal diseases when inoculated with constructs expressing human or porcine enterotoxins.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.00893-08

Reference40 articles.

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